Bioinorganic activity of technetium radiopharmaceuticals

Adverse Reactions to Radiopharmaceuticals (ARRP): Particularly To Technetium Radiopharmaceuticals

Radiopharmaceuticals are radioactive compounds that are prepared by a radiopharmasist and used in Nuclear Medicine departments for diagnostic or therapeutic purposes of human diseases. They are generally used i.v. so they have to be sterile and apyrogenic like other parenteral drugs. Effecting in a correct way and localising in the desired tissue with a sufficient amount, physicians and Nuclear...

Adsorption of some technetium-99m radiopharmaceuticals onto disposable plastic syringes.

OBJECTIVE The purpose of this study was to determine the adsorption behavior of some widely used, commercially available 99mTc radiopharmaceuticals onto different types of plastic syringes. METHODS Kits were reconstituted with 99mTc-pertechnetate diluted with 0.9% saline to produce maximum radioactive concentrations, as stated by the manufacturers. Aliquots of the solutions were transferred t...

Direct Technetium radiopharmaceuticals production using a 30MeV Cyclotron

BACKGROUND AND THE PURPOSE OF THE STUDY Technetium-99m is the major radionuclide used in the world and mainly is provided by fission product. However extensive research has been conducted on the use of accelerators for production of (99m)Tc. This investigation reports the production of (99m)Tc radioisotope using cyclotrons and the preparation, quality control and biodistribution studies of four...

Bioinorganic Chemistry Bioinorganic Chemistry

Click-to-Chelate: development of technetium and rhenium-tricarbonyl labeled radiopharmaceuticals.

The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores. Reaction of azide-functionalized molecules with alkyne prochelators by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC; click reaction) enables the simultaneous synthesis and conjugation of tridentate chelating systems for the...